男性肺癌患者外周血性激素水平的测定及其临床意义

Levels of sexual hormones in plasma of male patients with lung cancer and their clinical significance

目的 检测男性肺癌患者外周血性激素水平并探讨其对肺癌诊断、治疗的价值。方法 采用磁性微粒分离的免疫酶联分析测定方法测定 70例男性肺癌患者、30例男性慢性阻塞性肺病 (chronicobstructivepulmonarydisease ,COPD)患者和 30例健康男性血清中雌二醇 (estradiol,E2 )、孕酮 (progesterone ,P)、睾酮 (testos terone ,T)、卵泡刺激素 (folliclestimulatinghormone ,FSH)和黄体生成素 (lutenisinghormone ,LH)水平 ,并探讨男性肺癌组患者肿瘤的大小、病理类型、分期与性激素水平的关系。结果 与正常组相比 ,男性肺癌组T水平降低(P <0 .0 5 ) ,E2 水平和E2 /T明显升高 (P <0 .0 0 1) ;与COPD组相比 ,男性肺癌组患者E2 水平、E2 /T明显降低(P <0 .0 0 1) ,而睾酮水平无明显差异 (P >0 .0 5 )。E2 水平、E2 /T比值与肿瘤大小和分期有密切关系 (P <0 .0 1)。与鳞癌组相比 ,腺癌组T水平降低 (P <0 .0 5 ) ,其它性激素水平与肿瘤的类型无明显关系 (P >0 .0 5 )。结论 检测男性肺癌者血清E2 、T水平和E2 /T对男性肺癌的诊断和判断患者病期具有一定的辅助价值。

Objective To determine the levels of several sexual hormones in plasma of male patients with lung cancer and to evaluate their clinical significance. Methods The levels of estradiol (E 2), progesterone (P), testosterone (T), follicle stimulating hormone(FSH), and lutenising hormone(LH) in plasma of 70 patients with lung cancer, 30 patients with chronic obstructive pulmonary disease(COPD), and 30 healthy men were measured by enzyme immunoassay magnetic solid phase(IEMA). The difference of sexual hormone levels was compared among male lung cancer patients by different tumor size, clinical stage, and pathological type. Results The E 2 level and the ratio of E 2/T (24.7?ng/L±19.1?ng/L and 10.9 ±9.8) were significantly increased in male patients with lung cancer than those in normal adults(12.6?ng/L±4.8?ng/L and 3.4±1.6) (P<0.001). Compared with control group, the level of plasma T in male patients (3.3?μg/L±1.5?μg/L) was significantly decreased (P<0.05), but there was no difference between lung cancer group and COPD group (P>0.05). The level of E 2 and the ratio of E 2/T had close relationship with the tumor size and clinical stage (P<0.01). Compared with squamous cell carcinoma group, the level of plasma T in adenocarcinoma patients (2.3?μg/L±1.2?μg/L) was significantly decreased (P<0.05), but other levels of sexual hormones didn't relate to the pathological type of tumor (P> 0.05 ). Conclusion The results suggest that the determination of the levels of T, E 2 and the ratio of E 2/T might be helpful for the diagnosis of male lung cancer and to predict the stage of male patients.