五味子中提取α-葡萄糖苷酶抑制剂的研究

Study on the characteristics of α-glucosidase inhibitor from Schizandra Chinensis

目的从中药五味子中提取分离α 葡萄糖苷酶抑制剂。方法利用浸提、超滤、柱层析、醋酸铅沉淀等方法进行纯化。结果初步分离得到α 葡萄糖苷酶抑制剂。结论该抑制剂成分为大分子糖苷类物质 ,相对分子量在 5万以上 ,抑制类型为非竞争性抑制。

PurposeThe aim is to study α-glucosidase inhibitor from Schisandra Chinensis(Turcz.)Baill.MethodsThe inhibitor was purified by soaking,ultrafiltration,ion-exchange chromatography and Lead Acetate deposition.ResultsA α-glucosidase inhibitor was obtained.ConclusionThe inhibitor was a kind of non-competition inhibitor with large molecular weight of over 5×105D.