高原肺水肿患者血浆ET和SOD测定及其意义

The changes of plasma endothelin and superoxide dismutase of high altitude pulmonary edema patients

目的 :探讨高原肺水肿 (HAPE)患者血浆ET和SOD的水平及在发病中的作用 ,方法 :采用放射免疫法测定血浆ET、SOD、AⅡ 的含量 ,用Griss反应法检测NO水平。结果 :HAPE患者血浆NO和SOD水平显著低于高原健康组 (P <0 0 1 ) ,ET和AⅡ 水平显著高于高原健康组 (P <0 0 1 ) ,结论 :血管活性物质平衡失调及血管内皮细胞损伤是HAPE发病的重要原因之一。

Objective:To study the changes and pathogenetic interaction of plasma endothelin(ET) and superoxide dismutase(SOD) on high altitude pulmonary edema patients of Tibet. Methods:The level of plasma ET、SOD、Angiotensin Ⅱ(AⅡ) and nitric oxide(NO) were detected(ET、SOD、AⅡ by radioimmunoassay,No by Griss reaction method) on 20 high altitude pulmonary edema patients and 20 healthy adults at high altitude. Results:The plasma NO and SOD concentration of high altitude pulmonary edema patients were lower than those of healthy adults significantly(P<0 01).The plasma ET and AⅡ concentration of high altitude pulmonary edema patients were higher than those of healthy adults(P<0 01). Conclusion:The increasing of plasma ET、AⅡ and decreasing of plasma NO、SOD concentration of high altitude pulmonary edema patients may be related with dysequilibrium of vessel active mass and vascular endotheliocyte injury.