帕金森病与血管性帕金森综合征的脑诱发电位比较研究

The value of brain evoked potentials on the patients with Parkinson′s disease or vascular Parkinson′s syndrome

目的 探讨脑诱发电位 (brainevokedpotentials ,BEPs)对帕金森病 (PD)和血管性帕金森综合征 (VPS)的诊断价值与区别。方法 测定 39例PD、32例VPS和 2 0例正常人的躯体感觉诱发电位 (SEP)、脑干听觉诱发电位 (BAEP)、视觉诱发电位 (VEP)、事件相关电位 (ERP) ,并进行比较分析。结果 PD组和VPS组的VEP和BAEP与正常对照组比较无显著性差异。SEP在PD组的异常率为 2 8.2 %,异常位置点主要是N50 、P60 ;在VPS组的异常率为 5 6 .3 %,异常位点有 5个 ,与正常对照组相比较均有显著性差异 (P <0 .0 1) ,但N50 、P60 差异更为显著。ERP在PD组的异常率为 6 4.1%,在VPS组异常率为5 9.4%,异常特点是前者在N2 、P3 位置点波幅降低和PL延长 ,后者N1、N2 、P3 位置点的波幅和PL均有改变。结论 在PD、VPS患者BEPs的检查结果中 ,SEP和ERP异常率较高 ,但两组的异常形式不同 。

s:?Objective To explore the value of the brain evoked potentials(BEPs) on the patients with Parkinson′s disease (PD)or vascular Parkinson′s syndrome(VPS).Methods Somatosensory evoked potential (SEP),Visual evoked potential(VEP),Brainstem auditory evoked potential(BAEP) and Event related potential(ERP) were mesured in 39 cases with PD,32 cases with VPS and 20 cases of healthy control.Results It was showed that there was no differences of VEP and BAEP in PD and VPS group when compared with healthy control.The abnormal rate of SEP was 28.2% in PD,the locations of abnormality were mainly at N 50 ,P 60 .The abnormali rate of SEP was 56.3% in VPS,the locations of abnormality were at five points,comparing with healthy control,the differences were remarkable in PD and VPS group( P <0.01).The abnormal rate of ERP was 64.1% in PD,and 59.4 % in VPS.The features of abnormality were lower of wave amplitude at N 2,P 3 and longer of PL in PD,and that the wave amplitude of N 1,N 2,P 3 and PL have all changed in VPS.Conclusion The abnormal rates of BEPs on the patients with IPD and VPS are more higher in SEP and ERP,but the pattern of their abnormality is not alike at the locations and amplitude.These suggests that the locations and the range of damage on the central nervous system are significantly difference in them.