5种选择性去窦弓神经方法对清醒大鼠动脉压力感受反射敏感性的影响

THE EFFECT OF SINOAORTIC DENERVATION BY FIVE SELECTIVE METHODS ON BAROREFLEX SENSITIVITY IN CONSCIOUS RATS

目的 :测定左、右单侧去窦弓神经、双侧去窦弓神经、双侧去主动脉神经和双侧去窦神经后清醒大鼠动脉压力感受反射敏感性改变。方法 :用改良的Smyth方法测定动脉压力感受反射敏感性 ;急慢性实验分别在手术后 1d、2 1d进行 ,以比较其代偿功能。结果 :去窦弓神经后大鼠动脉压力感受反射敏感性显著下降 ;左右单侧间有显著性差异 ,并有明显的相互代偿 ;去主动脉神经后的动脉压力感受反射敏感性的下降比去窦神经明显 ,且前者无明显代偿而后者有明显代偿。结论 :对动脉压力感受反射敏感性来说 ,右侧窦弓神经的作用比左侧重要 ,但代偿能力相当 ;且主动脉神经的作用比窦神经重要 。

Aim:To measure the acute and chronic effects of left or/and right sinoaortic denervation(SAD),aortic denervation,and sinusde nervation on baroreflex sensitivity(BRS) in conscious rats.Methods:BRS was measured by means of a modified Smyth's method.The acute and chronic effects experiments were executed in 1 st and 21 st days after selective SAD respectively to compare the compensatory function.Results:①BRS decreased significantly after selective SAD.BRS of right SAD was significantly lower than that of left SAD,but they were able to compensate for each other.②The decrease in BRS of aortic denervation was more significant than that of sinus denervation,but the former had no significant compensatory function,which was different from the latter.Conclusion:As for baroreflex,right sinoaortic nerves are more important than the left,but their ability to compensate for each other is comparable.Meanwhile,aortic nerves are more important than sinus nerves,and so is their compensatory function.