新型餐时血糖调节剂-那格列奈

Nonsulfonylurea PGR--Nateglinide

那格列奈，Ｎ－（反式－４－异两基环己烷羰基）－Ｄ－苯丙氨酸为一新型餐时血糖调节剂，能抑制胰腺β－细胞中ＡＴＰ敏感的Ｋ＋通道，增加细胞内Ｃａ２＋浓度，使血浆内胰岛素水平升高，具有起效快、作用时间短的特点。本文主要对那格列奈的作用机理、药代动力学、临床疗效进行了介绍。

N-[(trans-4-isopropylcyclohexyl)-carbonyl]-D-Phenylalanine, a novel oral antidiabetic agent,is a nonsulfonylurea insulinotropic agent. It inhibited the ATP-sensitive K+channel and increased cytosolic free Ca2+ concentration in pancreatic:A-cells. Oral administration of nateglinide produced a rapid onset and short duration of hypoglicemic action with an acute increase in plasma insulin concentration. In thes paper, we reviewed its mechanism, pharmacokinetics, clinical treatment.