病毒性肝炎患者血清总胆汁酸测定及其意义

THE DETERMINATION OF TOTAL BILE ACID IN THE SERUM OF PATIENTS SUFFERING FROM VIRAL HEPATITIS AND ITS SIGNIFICANCE

目的：探讨各型病毒性肝炎血清总胆汁酸（TBA）水平及其临床意义。方法：检测210例病毒性肝炎患者空腹血清TBA水平并与常规肝功能酶学指标ALT、AST、ALP、GGT作对比分析。结果：各型病毒性肝炎患者血清TBA与对照组比较均有显著性差异（P ＜ 0．01）；慢性肝炎轻、中、重度及肝炎后肝硬化患者血清TBA异常率与ALT、AST、ALP、GGT异常率比较有显著性差异（P ＜ 0．01）。结论：病毒性肝炎患者血清TBA水平对反映肝功能受损程度有较高灵敏性，对判断病情活动程度及预后有一定临床价值。

Objective： To investigate total bile acid （TBA） level in the serums of several types of viral hepatitis and to know its clinical significance． Method： The serums were got from 210 cases of the patients with viral hepatitis． TBA level and the ordinary enzyme index of the liver function were comparatively analyzed． Results： Serum TBA level of the patients with several types of viral hepatitis showed significant different compared with control group （P ＜ 0．01）； the unusual rate of Serum TBA from patients with chronic hepatitis and cirrhosis following hepatitis was significant difference compared with ALT，AST，ALP and GGY abnormal rate （P ＜ 0．01）． Conclusion： The level of serum TBA from the patients with viral hepatitis can reflect damage extent of the live function with higher sensitivity and it has some clinical values in judging damage extent and prognosis of the disease．