大剂量维生素C对早期出血性休克的治疗作用

Therapeutic Effect of High Dosage of Vitamin C on Hemorrhagic Shock in Rabbits

目的 探讨大剂量维生素C对休克时血液流变学及血流动力学的作用。方法 将 18只兔经股动脉放血至休克后 ,分成维生素C治疗组和对照组。分别测定失血前后血流动力学指标、血液流变学指标及血浆丙二醛(MDA)含量。结果 对照组血流动力学、血液流变学无明显改善 ,血浆MDA水平升高。维生素C组以上各指标均有明显好转。结论 维生素C能改善休克时血液流变学和血流动力学 ,因而有明显的抗休克作用。

Objective To study the therapeutic effect of vitamin C in high dose on hemodynamics and hemorheology when hemorrhagic shock induced. Methods 18 shock rabbits induced with bleeding were divided into control group treated with saline and test group treated with vitamin C. The indices of hemodynamics and the property of hemorheology and level of MDA in plasma before and after hemorrhage were measured respectively. Results The indices of hemodynamics and the property of hemorheology in vitamin group were improved significantly,but the level of MDA was reduced as compared with the control group .Conclusion Vitamin C can improve hemodynamics and hemorheololgy when hemorrhagic shock induced, therefor vitaminC may be used to treat hemorrhagic shock.