Cyclin D1蛋白和P16蛋白在子宫内膜癌中的表达及其相关性研究

Expression of Cell Cycle Associated Proteins Cyclin D1 and P16 in Endometrial Carcinoma and the Correlation between Their Expression Status

目的 了解细胞周期调控蛋白 Cyclin D1,P16在子宫内膜癌中的表达及与临床特征的关系 ,并探讨两者表达的相关性。方法 用免疫组化 SP法检测 64例子宫内膜癌标本中 Cyclin D1蛋白和 P16蛋白的表达。结果 Cyclin D1蛋白的阳性表达率为 5 4.68% ,其表达与 FIGO分期有关 ;P16蛋白的阳性表达率为 5 3.13% ,其表达与年龄、组织学分级和 FIGO分期有关 ;Cyclin D1蛋白和 P16蛋白的表达有相关性 (r=- 0 .40 0 7)。结论 细胞周期调控基因相关蛋白 Cyclin D1和 P16与子宫内膜癌的发生和发展有关 。

Objective To study the expression of cell cycle associated proteins Cyclin D1, P16 in endometrial carcinoma and their correlation to clinical parameters, and to assess the correlation between their expression status. Methods\ Immunohistochemical method was used to detect Cyclin D1 and P16 expressions in 64 cases of endometrial carcinoma. Result\ The positive rate of Cyclin D1 was 54.68%. The Cyclin D1 expression was significantly associated with FIGO stage ( P< 0.05). The positive rate of P16 was 53.13% and its expression was related to age, histological grade and FIGO stage ( P< 0.05). There was an inverse correlation between Cyclin D1 and P16, r =-0.4007( P< 0.01). Conclusion\ Cyclin D1 and P16 had cooperative effect and may play an important role in the developement and progression of endometrial carcinoma