瘦素与其它激素水平在儿童青春期中的变化规律及相互关系研究

Study on Changing Regularity of Leptin and Level of Other Hormones during Puberty in Children

目的 研究瘦素与其它激素在儿童青春发育中的变化规律及相互关系。方法 对 30 0名 10～ 16岁健康儿童血中的瘦素、性激素、生长激素和胰岛素水平进行检测。结果 随着年龄的增长 ,瘦素水平在男孩中呈现由低、高、低的变化规律 ,在女孩中呈现逐渐增高趋势 ;性激素水平在两组儿童中呈现增高趋势 ;生长激素水平的变化规律表现为在某一年龄段的突增 ,并且其在男女孩中的突增时间不同 (男孩 :14～ 15岁 ;女孩13～ 14岁 ) ;胰岛素水平的变化无明显规律。另外还发现 ,男孩睾酮与瘦素呈高度负相关 (r=- 0 93,P <0 0 1) ;女孩雌二醇与瘦素呈高度正相关 (r=- 0 95 ,P <0 0 1) ;生长激素在男孩中与瘦素呈负相关 (r =- 0 6 9,P <0 0 5 ) ,在女孩中与瘦素呈正相关 (r=- 0 6 7,P <0 0 1) ;胰岛素在女孩中与瘦素呈正相关 (r =0 5 4,P <0 0 5 )。结论 瘦素对儿童青春期的启动可能具有重要作用 ,并且其在女孩青春期发育中可能发挥比男孩更为重要的作用 ;瘦素与生长激素相关关系的两性差异可能是造成男女孩生长突增时间不同的原因之一。

Objective To study the changing regularity of leptin and some hormones during puberty in children and the relationship between them.Method The levels of leptin?sex hormones?growth hormone(GH)and insulin(INS)were measured in blood in 300 healthy children,aged 10～16.Results With age increasing,leptin levels ranged from low to high to low in boys,while leptin had increasing trendency in girls.Sex hormones had increasing trendency in both groups.The changing of GH levles showed sudden increase and sudden decrease in all groups,but the time of suden increase in boys differed from that in girls(boys:14～15 years;girls:13～14 years).There had no obvious regularity in INS changing.There was significant negative correlation between testosterone and leptin in boys( r=-0 93,P<0 01 ),while the estradiol was positive correlated with leptin in girls( r=0 95,P <0 01).GH was negative correlated with leptin in boys( r=-0 69,P <0 05)and positive correlated with leptin in girls( r=0 67,P <0 01).There waspositive correlation between INS and leptin in girls( r=0 54,P <0 05).There was positive correlation between INS and leptin in girls( r=0 54,P<0 05 ).Conclusion Leptin might have important effect on pubertal onset in children and play a more role in pubertal development in girls compared with boys.There are gender differences in the corrleations between leptin and GH,which may cause the differences of the timing of sudden growth in boys and girls.