不同硒水平对氟中毒大鼠脂质过氧化和抗氧化能力及甲状腺功能的影响

Effects of selenium at different levels on lipid peroxidation, the capatity of anti-oxidation and thyroid in rats with fluorosis

目的 探讨不同水平硒对氟中毒大鼠血清抗氧化酶ＳＯＤ、ＧＳＨ－Ｐｘ活力、丙二醛（ＭＤＡ）及ＦＴ３、ＦＴ４、ＴＳＨ含量的影响。方法 ９６只ＳＤ大鼠随机分为４组，３个实验组均饮１００ｍｇ／Ｌ高氟水，其中２组饲加硒饲料，加硒量分别为２、３ｍｇ／ｋｇ，实验期４个月。结果 单纯高氟组与对照组相比大鼠血清ＳＯＤ、ＧＳＨ－Ｐｘ活力降低，ＦＴ３、ＦＴ４含量显著升高，加硒加氟组与单纯高氟组相比ＳＯＤ、ＧＳＨ－Ｐｘ活力显著升高，ＦＴ３、ＦＴ４含量显著下降，且加硒量较大组上述变化增强，各组ＭＤＡ、ＴＳＨ含量无明显区别。结论 高氟可抑制机体抗氧化酶活力，使甲状腺功能亢进；硒可持抗氟的这种作用且在一定程度上随硒量增加拮抗作用增强。

Objective To study the effects of selenium at different levels on the activities of SOD and GSH -Px and contents of MDA、FT3、FT4、TSH in serum of rats with fluorosis. Methods 96 SD rats were randomly aeperated to 4 groups. 100mg/L fluorosis was added in drinking water in three treated groups. At the same time there are two tested groups were supplemented selenium in fodder, the amount of selenium was 2mg/kg and 3mg/kg. Results The activities of SOD、GSH-Px decreased significantly and the contents of FT3、FT4 increased significantly in the simply fluoride - treated group compared with control group the activities of SOD、GSH - Px increased siginificant- ly and the contents of FT3、FT4 decreased significantly in two groups of Se supplemented compared with non-Se groups. The variation said in front was obvious in the group with mere selenium. the differentation on the content of MDA and TSH was't significant in the four groups. Conclusions Fluoride could decrease the capacity of antioxidaase and make thyroid functions hyperfunction. Se could antagonize the functions of fluoride. To certain extent, the antagonism was powerful with the amount increasing of selenium.