乳腺癌血管内皮生长因子过度表达及nm23-H1低表达与淋巴结转移的关系

RELATIONSHIP BETWEEN VEGF OVER-EXPRESSION AND nm23-H1 LOW-EXPRESSION IN BREAST CANCER WITH LYMPHATIC METASTASIS

目的 :探讨血管内皮生长因子 (VEGF)及 nm2 3- H1表达与乳腺癌生物学行为及淋巴结转移的关系。方法 :应用免疫组化方法对 32例乳腺癌中 VEGF和 nm2 3- H1表达进行测定。结果 :VEGF过表达或 nm 2 3- H1低表达者淋巴结转移率明显高于正常表达者 (P<0 .0 1,P<0 .0 5 )。在 VEGF过表达及 nm2 3- H1低表达同时存在时 ,淋巴结转移率更高。结论 :通过 VEGF及 nm2 3- H1表达检测对正确评价乳腺癌淋巴结转移的可能性及其预后有较大意义 ,两者同时检测意义尤为重大。

Objective:To determine the relationship between VEGF and nm23-H1expression level.Method:To determine VEGF and nm23-H1 of 32 patients with breast cancer by immunohistochemistry .Result:Lymphatic metastasis rate significantly increated in the patients with either VEGF over-expression or nm23 low-expression (P<0.01,P<0.05).nm23-H1 low-expression rate was significantly higher in VEGF over-expression group than that in the normal control group (P<0.05).Conclusion:Detection of VEGF and nm23-H1 expression levels plays an important role in predictions of occurrence of lymphatic metastasis and the prognosis in breast cancer, particularly for those represent both VEGF over-expression and nm23-H1 low-expression .