耳鸣消口服液药效学研究

Pharmacodynamics Study on the Ermingxiao Oral Liquid( 耳鸣消口服液)

目的 :研究耳鸣消口服液治疗耳鸣的机制。方法 :运用血瘀动物模型观察其对家兔血液流变学、大鼠软脑膜微循环、耳廓微循环、小鼠脑循环障碍性缺氧的影响及其对小鼠的镇静催眠作用。结果 :该制剂能改善血液流变学及大鼠软脑膜微循环和耳廓微循环 ,对小鼠脑循环障碍性缺氧具有明显保护作用 ,并可增强氯硝安定对小鼠的镇静催眠效应。结论

Objective:To study the treatment mechanic of Er mi ngxiao Oral Liquid (EOL) on tinnutus.Method:To observe the effects of EOL on blood rheology of rabbit,microcirculation of cerebral pia m ater and auricula of mouse,ischemia because of microcirculation dysfunction,sed ation and hypnotism.Result:EOL could improve the blood rheology ,circulation of cerebral pia mater and auricula of mouse,and protect the ische mia because of brain circulation dysfunction,and improve the effect of Clonazepa m on hypnotism and sedation.Conclusion:EOL could improve the mic rocirculation of inner ear and have sedation effect.