自由基、脑血流速度与蛛网膜下腔出血后脑血管痉挛关系的探讨

The relationship of free radicals ,cerebral blood flow velocities and cerebral vasospasm following subarachnoid hemorrhage

目的 :探讨自由基、脑血流速度与蛛网膜下腔出血后脑血管痉挛的关系。方法 :对 2 8例蛛网膜下腔出血(SAH)患者及 39例健康人进行血自由基 (TAO、MDA)和经颅多普勒 (TCD)超声检测。结果 :与对照组相比 ,病人组TAO、MDA显著升高 ,且均不同程度的脑血管痉挛 (CVS)。结果 :SAH后血自由基明显升高 ,是导致 CVS的重要因素 。

Objective: To investigate the relationship of free radical,cerebral blood flow velocities and cerebral vasospasm (CVS) following subarachnoid hemorrhage (SAH).Methods: The blood free radicals(TAO,MDA) of 28 SAH cases and 39 healthy persons were monitored. The cerebral blood fiow velocities were monitored by transcranial Doppler ultrasonography(TCD). Results: To compared with the healthy group , the TAO and MDA of the patients group increased obviously and all different degrees of CVS were discovered in patiens group. Conclusion: The increase of the free radicals following SAH was an important factors in CVS occurrence which increased obviously cerebral blood flow velocities.