血清胆碱酯酶在肝病诊疗中临床意义的探讨

The significance of serum cholinesterase in diagnosis and treatment of hepatic disorders

目的 :探讨血清胆碱酯酶在肝病诊断中的价值。方法 :检测 75例各型肝病患者及 2 6例正常对照者血清胆碱酯酶(CHE)、丙氨酸转移酶 (AL T)、γ一谷氨酰转肽酶 (GGT)、白蛋白 /球蛋白 (A/G)比值 ,并分析其临床意义。结果 :与健康对照组相比 ,各型肝病患者的血清 AL T及急性黄疸性肝炎组的血清 GGT活性均显著升高 (P <0 . 0 1)。而轻度及中度慢性肝炎及急性黄疸性肝炎患者血清 CHE活性未见明显变化 (P >0 . 0 5 ) ;此外重度慢性肝炎、肝炎后肝硬化患者的 CHE活性和 A/G比值均明显降低 (P <0 . 0 1)。结论 :血清 AL T、 GGT、CHE是反映肝功能的酶类 ,CHE尤其是提示肝细胞受损的敏感指标 。

Objective: To determine the value of serum cholinesterase in treatment and diagnosis of hepatic disorders.Methods:The clinical significance and activities of cholinesterase(CHE), alanine transaminese(ALT), gamma glutamyl transpeptidase (GGT) and albumin/globulin ratio of serums in 75 patients with different disorders of liver and 26 healthy subjects were investigated.Results:Compared with controlling group, the serum ALT activity of patients in all groups and serum GGT activity of patients with acute jaundice hepatitis were markedly increased (P<0.01), respectively. But, there were no obvious elevation in serum (CHE) activity in patients with sligtly and middle chronic hepatitis and acute jaundice hepatitis(P>0.05), Moreover,serum CHE activity and A/G ratio in serious chronic hepatitis and actively phases of liver cirrhosis with hepatitis significantly decreased than those in healthy group(P<0.01). Conclusion: The measurements of serum activities of ALT?GGT and CHE reflects the functions of liver. The CHE is especially sensitive to indicate the damage of hepatic cell, which is favor of diagnosis and prognostic analysis of hepatic disease.