单纯性肥胖儿童最大有氧能力与Fg基因多态性的关联研究

Fibrinogen Gene Polymorphism and Max Aerobic Capacity(VO_2max) in Obese Children

纤维蛋白原（Ｆｑ）基因ＴａｑⅠ限制性内切酶位点的多态性与儿童单纯性肥胖及最大有氧能力关联，Ｔ１纯合子肥胖的健康风险较高，心肺机能有一定局限。依本研究结果我们推测：儿童单纯性肥胖这一表型可能为基因依赖性。Ｆｇ基因可能对此表型有一定程度的调控，此外，该基因可能与调控人类有氧能力的基因连锁。本研究的现实意义是：就Ｆｇ基因而言，不同基因型个体具有相异的健康风险阈值，某种等位基因的携带者可能在心肺机能方面具有一定程度的劣势。这不仅有助于对肥胖儿童的早期监护，而且还为运动员的早期筛选提供依据。

Association has been found between fibrinogen gene TaqI polymorphism with obese children and aerobic capacity. T1 homozygotes have higher risk for obesity and lower aerobic capacity. It is suggested that obese children are dependent on genotype. Fibrinogen gene may regulate those phenotypes to some extent. In addition, it may have association with aerobic capacity. Therefore, as for fibrinogen gene, subjects with different genotype may have different health risk threshold and subjects with some genotype may be inferior to others in cardiorespiratory fitness. Those results may be served as bases in prevention of health risk and choosing athlete at early age.