运动训练对应激大鼠免疫功能的影响

The Effect of Exercise Training on Immune Function in Rats after Cool Stress

为了研究运动训练对应激大鼠免疫功能的影响及其调节机制，对大鼠进行为期４周的中、小负荷的运动训练，并在运动训练后期施加冷刺激，测定大鼠外周血液ＮＫ细胞的数量和β－ＥＰ的含量。结果：①应激组血液中ＮＫ细胞显著低于对照组，但β－ＥＰ含量显著高于对照组，表明冷应激增加内源性β－ＥＰ的释放，从而使外周ＮＫ细胞数量下降，抑制机体的免疫功能；②经过４周的运动训练后，３０ｍｉｎ训练组和６０ｍｉｎ训练组ＮＫ细胞均显著高于对照组，β－ＥＰ含量低于对照组；同时，应激＋３０ｍｉｎ训练组和应激＋６０ｍｉｎ训练组ＮＫ细胞数量显著高于应激组，β－ＥＰ含量显著低于应激组。结果表明，运动训练通过提高机体生理和心理应激能力，减少机体应激时内源性β－ＥＰ的释放，使血液中 ＮＫ细胞数量增加，维持机体免疫功能的稳定。

In order to explore the effects of exercise training on immune function and regulating mechanism, SD rats were conducted on exercise training for 4 weeks and exerted on cool stress for 10 days in the later stage of training, NK cell number and β-endorphin(β-EP) content in peripheral blood were measured. The results: ①NK number in stress group was lower than that in control group, β-EP concentration in stress group was higher than that in control group. It indicated that cool stress might induce organism to produce psychosomatic changes and increase the release of endogenous β-EP which made the decrease of NK number, and restrain immune function. ② After 4 weeks training, NK cell number in 30 min and 60 min training group were higher than that in control group, but β-EP content were lower than that in control group. At the same time, NK cell number in stress and 30 min training and in stress and 60 min training group were higher than that in stress group, but β-EP content were lower than that in stress groups significantly. It indicated that exercise training might act as an active coping to improve physiological and psychological stress and decrease the release of endogenous β-EP and increase NK cell number, and maintain the stabilization of immune function.