MMP2、MMP9在肾癌中的表达及意义

Expressions of Matrix Metalloproteinases 2 and 9 in Human Renal Cell Carcinoma

目的 :探讨基质金属蛋白酶 2 (MMP2 )和基质金属蛋白酶 9(MMP9)在肾癌中的表达及预后的关系。方法 :采用S P法对 4 1例肾癌、5例正常肾组织的MMP2和MMP9进行检测 ,结合临床资料进行分析。结果 :MMP2和MMP9的阳性表达分别为 5 6.1%和 4 3 .9% ;MMP2和MMP9在高分期、高分级肾癌中表达的阳性率较低分期、低分级肾癌高 ( P <0 .0 5 ) ;MMP2和MMP9阳性表达与阴性表达 5年生存率有显著差异 ( P <0 .0 5 )。MMP2和MMP9的阳性表达高的肾癌患者易侵袭、转移 ,预后差。结论 :MMP2和MMP9参与肾癌的侵袭和转移 ,可作为判断预后的指标。

Objective: Our aim was to study the effect of expressions of metrix metalloproteinases 2(MMP2) and MMP9 on the prognosis of renal cell carcinoma (RCC) Methods: Forty one specimens of human RCC and kidney tissues from 5 healthy people as control were assessed by using immunohistochemical method (S P method). Results: The positive expressions of MMP2 and MMP9 in human RCC were 56.1%, 43.9% respectively.The expressions of MMP2 and MMP9 in pT3 and pT4 tumors were significantly higher than those in pT1 and pT2 tumors (P<0.05).Their expressions in G2 and G3 tumors were significantly higher than those in G1 tumors (P<0.05). the expected survival time was shorter in patients with higher expressions of MMP2 and MMP9. Conclusion: The MMP2 and MMP9 may have an important role in the invasion and the metastasis, which suggested that the expression of MMP2 and MMP9 was useful in RCC prognosis.