妊高征患者母血、脐血白细胞介素-6与肿瘤坏死因子的研究

Levels of Interleukin 6 and Tumor Necrosis Factor of Maternal and Umbilical Serum in Pregnancy Induced Hypertension

目的 :探讨白细胞介素 6(IL 6)、肿瘤坏死因子 α(TNF α)与妊高征发病机理的关系。方法 :采用放射免疫法检测重度妊高征患者 3 0例 (妊高征组 )母血、脐血中IL 6与TNF α的含量。并以同期正常妊娠妇女 3 0例作对照 (正常妊娠组 )。结果 :妊高征组母血中IL 6含量为 ( 163 .3 0± 64.82 )ng/L ,TNF α含量为 ( 1.5 2± 0 .3 1)ng/L ,均较正常妊娠组显著增高 (P <0 .0 1,P <0 .0 1)。妊高征组脐血中IL 6含量为 ( 13 5 .2 0± 84 .16)ng/L ,TNF α含量为 ( 1.3 1± 0 .16)ng/L ,也均较正常妊娠组明显升高 ( P <0 .0 1;P <0 .0 1)。结论 :IL 6与TNF α参与了妊高征的血管内皮损伤过程 ,两种细胞因子的升高与妊高征的发生密切相关。

Objective: Our aim was to study the relationship between interleukin 6 (IL 6), tumor necrosis factor (TNF α) and the pathogenesis of pregnancy induced hypertension (PIH). Methods: Radioimmunoassay was used to detect the levels of IL 6 and TNF α in maternal and umbilical serum of severe PIH and normal pregnancy.Results: The levels of IL 6 (163.30±64.82 ng/L) and TNF α(1.52±0.31 ng/L)in maternal serum in severe PIH were significantly higher than those in normal pregnancy group (P<0.01, P<0.01). The levels of IL 6(135.20±84.16 ng/L) and TNF α( 1.31 ±0.16 ng/L) in umbilical serum of severe PIH were also significantly higher than those in normal pregnancy group (P<0.01, P<0.01). Conclusion: The IL 6 and TNF α cooperate in the damage process of vascular endothelial cell. The high levels of the cytokin play an important role in the pathogenesis of PIH.