心脏起搏早期对血浆血管性假性血友病因子和可溶性P-选择素的影响及意义

The Value of Plasma Von Willebrand Factor and Soluble P-Selectin in the Early Cardiac Pacing.

探讨心脏起搏早期对血浆血管性假性血友病因子 (VWF)和可溶性P 选择素 (SPS)的影响及其意义。对 32例不同方式起搏患者及 2 0例对照者采用酶联免疫双抗夹心法测定术前及术后 7～ 8天的VWF及SPS。结果 :心脏起搏患者术前存在高水平的VWF、SPS ,术后血浆VWF及SPS随临床症状的改善而显著下降 ,但仍高于正常对照。结论 :心脏起搏早期明显降低血浆VWF及SPS水平 ,由于血浆VWF、SPS分别是反映血管内皮功能和血小板活性的特异敏感分子标志物 ,因此 ,心脏起搏早期在改善临床症状的同时伴有血管内皮功能的改善和血小板活性的降低。而起搏患者术前、术后高水平的VWF。

The study determined the value of plasma Von Willebrand factor (VWF) and soluble P selectin(SPS) in the early period of cardiac paicng patients.Plasma VWF and SPS concentrations were measured in 32 patients before and after pacing for 7～8 days.Comparisons were also made between the patients and 20 age and sex matched controls.After pacing the patients′ cardiac function had been improved from 2.8±0.5 to 1.8±0.4,atrial arrhythmias had been nearly completed controlled.Plasma VWF,SPS were significantly higher in the patients(either receiving physiological pacing or non physiological pacing)than those in the controls and normal levels.After pacing,VWF and SPS decreased significantly but still significantly higher than those in the controls.Conclusion:In the early time,cardiac pacing can significantly decrease vascular endothelial cells function and decrease platelets activation by improving cardiac function and controlling cardiac arrhythmias.