朗格罕斯细胞的分布、变化与口腔扁平苔藓发病及病变程度的关系

Distribution of Langerhans cell in oral lichen planus

目的：为进一步探讨口腔扁平苔藓的发病机制。方法：采用免疫组织化学方法，使用郎格罕斯细胞特异性标记ＣＤ１ａ单克隆抗体对３５例口腔扁平苔藓（ｏｒａｌ ｌｉｃｈｅｎ ｐｌａｎｕｓ，ＯＬＰ）进行研究。结果：ＣＤ１ａ＋的郎格罕斯细胞（Ｌａｎｇｅｒｈａｎｓ ｃｅｌｌ， ＬＣ）较对照组明显增多，分布更趋于上皮棘层及粒层，树突增多、增长。其数量和表达程度与ＯＬＰ病程、病变程度相关，不同组间有高度显著性（Ｐ＜０．０１）。结论：ＬＣ在ＯＬＰ的发病、发展中具有重要作用。

Objective: To study the distribution of Langerhans cell (LC) in oral lichen planuss (OLP). Methods: LCs in oral mucosa samples were examined with monoclonal CD1a antibody and an immunohistochemical technique(LAB method) in 35 cases of OLP and 6 cases of health control. Results: On average, in the samples of OLP the CD1a positive LCs counted under microscope in each field of 40 × 10 were 5. 78 in epithelial cell layer and 5.43 in lamina propria, while in the samples of health control those were 0.26 and 0.18 (P<0.01 OLP vs control). Conclusion: LC may play a important role in the pathogenesis of OLP.