人参皂苷Rg_2对失血性休克犬血流动力学的影响及抗脂质过氧化作用

Effect of Rg_2 on Hemodynamics of Hemorrhagic Shock and its A ntioxidation in Dogs

目的 :观察人参皂苷Rg2 对失血性休克犬血流动力学的影响及抗氧化作用。方法 :复制杂种犬失血性休克失代偿期病理模型 ,动脉放血至平均动脉压 (MBP)在 5 .33kPa以下 ,然后给予Rg2 0 .5 ,1mg·kg-1,参麦(SM) 10 0mg·kg-1,iv。观察 6h。结果 :人参皂苷Rg2 能明显升高失血性休克失代偿期犬MBP、左室内压 (LVSP)和左室内压最大变化速率 (±dp/dt) ;增强血清超氧化物歧化酶 (SOD)的活性 ,降低血清丙二醛 (MDA)含量 ;提高休克犬的存活率。结论 :人参皂苷Rg2 能明显改善失血性休克犬血流动力学多项指标 ,激活机体抗氧化能力 ,作用强于SM。

Objective:To investigate the protective effec t of Rg 2 on hemodynamics of hemorrhagic shock and its antioxidant properties. Method: Twenty mongrel dogs were randomly divided into Rg 2 gro up, Shen Mai group and control group. The hemorrhagic shock model was built in all dogs by artery bleeding and mean arterical blood presure was kept<5.33 kPa for 4.5 hours. Rg 2 0.5～1.0 mg·kg -1 and Shen Mai 100 mg·kg -1 w ere intravenously administered after hemorrhagic shock appeared.Result: Rg 2 signinficantly enhanced blood pressure, LVSP and ±dp/dt max on hemorrhagic shock dogs who had lost compensation ability. Rg 2 0.5～1.0 mg·kg -1 could reduce serum MDA, increase superoxide dismutase activity an d prolong survival rate of dogs after shock. All these data have statistically significant when compared to control group (P<0.05, P<0.01, P<0.001).Conclusion:These results suggest that Rg 2 is more potent and effect ive than Shen Mai in improving hemodynamic state and activiting SOD on hemorrhag ic shock dogs.