复圣散抗脑缺血再灌注损伤的机理研究

Study on the Mechanism of the Effects of Fusheng Powder Against the Lesions due to Cerebral Ischemia and Reperfusion

以大鼠缺血再灌注损伤为模型 ,采用放免测定及原位杂交等方法 ,观察复圣散对大鼠缺血再灌注损伤起到保护作用的机理。结果提示大鼠缺血再灌注后 ,cNOSmRNA、ETmRNA高表达引起NOS、ET含量增高 ,复圣散能够降低NOS。

The mechanism of the protective effects of Fusheng Powder against the lesions due to cerebral ischemia and reperfusion was studied in rats by radioimmunoassay and the in situ hybridization technique. It was found that the overdue expressions of cNOS mRNA and ET mRNA could increase the levels of NOS and ET, and Fusheng Powder could decrease the levels of NOS and ET and exert protective effects against the lesions due to cerebral ischemia and reperfusion.