观察补益药酒对血液凝固活性的作用

Study of the Effects of Medicinal Herbal Liquor on Blood Coagulation

为了观察补益药酒对小鼠和大鼠血液凝固和纤维蛋白溶解活性的稳态作用。利用小鼠体内血小板聚集实验 ,测定高胆固醇模型大鼠血浆t_PA与PAI 1含量和大鼠体内实验性血栓形成 3个环节实验。结果显示补益药酒可缓解ADP诱导的小鼠体内血小板聚集 ,缩短自主活动障碍时间 ;升高胆固醇模型大鼠血浆中t PA含量 ,降低PAI 1含量 ,使t PA与PAI 1比值恢复近于对照组水平 ,延长大鼠体内实验性血栓形成时间。证实补益药酒有缓解血液凝固和增加纤溶活性的作用 。

The effects of Medicinal Herbal Liquor (MHL) the blood coagulation and fibrinolysis were observed in mice and rats by the in vivo platelet aggregation test, the tissue plasminogen activator (t PA) and plasminogen activator inhibitor 1 (PAI 1) detection and the thrombosis test. The results showed that MHL could relieve the in vivo platelet aggregation and the disturbance of automatic activities in the mice; increase the level of t PA and decrease the level of PAI 1 in the rats with hypercholesterolemia, and make the ratio of t PA/PAI 1 restored nearly to normal; and delay the in vivo thrombosis in the rats. The results suggest that MHL has the effects of relieving blood coagulation and increasing fibrinolytic activity, and they comply with TCM theory of activating blood circulation and resolving stagnation.