活血、益气方药对心肌梗塞后心力衰竭大鼠血流动力学的影响

Experimental Study on the Effects of TCM Medicines for Activating Blood Circulation and Benefiting Qi on Hemodynamics in the Rats with Heart Failure due to Cardiac Infarction

采用冠状动脉结扎的方法造成大鼠心肌梗塞后心力衰竭的动物模型 ,分别应用活血、益气、气血注射液早期给药 4周及 8周、晚期给药 4周 ,以西药卡托普利作为对照药物。应用阻抗法观察给药后大鼠心功能的变化。结果显示早期给药组中均以活血组疗效最好 ,给药 4周与假手术组无差异 ,给药 8周与其余同期各给药组比较P <0 0 1或P <0 0 5。晚期给药组中益气组改善明显 ,但同期各治疗组间无差异。说明活血法则治疗心衰以及早期给药对逆转心衰的发生和恶化有更好的作用 ,推测其在改善心梗后左室重塑和细胞坏死。

The rat model of heart failure due to cardiac infarction was established by the method of the ligature of the coronary artery. Huoxue Injection (HI), Yiqi Injection (YI) and Qixue Injection were then administered to the model rats, 4 and 8 weeks for the early stage administration, and 4 weeks for the late stage administration. After the administration, the cardiac function of the model rats was observed by the impedance method, with that of the rats in the captopril treated group as a control. The results showed that the early stage administration of HI to the model rats exhibited better effects than the early stage administration of other 2 injections; and after the early stage administration for 4 weeks, there was no difference between the effects observed in the HI treated group and those in the sham operation group, and after the early stage administration for 8 weeks, there was a significant difference between the effects observed in the HI treated group and those in other groups ( P <0.01 or P <0.05). The results also showed that the late stage administration of YI to the model rats exhibited better effects than the late stage administration of the other 2 injections, but there was no difference between the effects observed in the YI treated group and those in other groups. The results suggest that HI administration to heart failure at early stage exerts better effects against heart failure and its exacerbation.