消癜益肾饮治疗过敏性紫癜肾炎的临床研究

Clinical Observation of the Effects of Xiaodianyishen Decoction for the Treatment of Henoch-Scnlein Purpura Nephritis

观察消癜益肾饮治疗 6 7例过敏性紫癜肾炎的疗效 ,治疗组分为毒热内蕴、脾肾两虚 2个证型 ,应用消癜益肾饮 1号、2号治疗 ,并设立对照组。结果显示 :治疗组总有效率 86 6 % ,对照组总有效率 6 3 3% ,治疗组与对照组比较 ,有显著性差异 (P <0 0 1)。经过检测 ,病人的免疫球蛋白、T细胞亚群、循环免疫复合物异常 ,提示本病存在免疫功能紊乱 ,经过治疗免疫功能获得改善。

The effects of Xiaodianyishen Decoction (XD) for the treatment of the patients with Henoch Schnlein purpura nephritis were observed. The disease was divided into two types according to the theory of traditional Chinese medicine (TCM), namely the internal breeding of toxic heat, and the deficiency of the spleen and kidney. 67 Patients were included in the treating group and 30 patients, in the control group. The treating group was given XD No.1 or XD No.2 according to the TCM type of the disease. The results showed that the total effective rate of the treating group was 86.6% and that of the control group was 63.3%, with a significant difference ( P <0.01). The laboratory tests found that the patients were with disorder of immunologic function, manifesting abnormality in immune globulin, T cell subpopulation and in circulating immune complex; and the results of the clinical observation suggest that XD can improve the immunologic function in the patients.