摘要
目的探讨不同G值的间断性 -Gx暴露对抗模拟失重下大鼠脑基底动脉血管反应性改变的效果。方法用大鼠在 1 .5G或 2 .6G的离心机上离心模拟不同G值间断性 -Gx暴露 ,分别给予大鼠 (尾悬吊 3wk) 1h/d -Gx作用 ,测定大鼠离体基底动脉血管环对KCl的收缩反应性。结果悬吊组大鼠基底动脉血管环对KCl的最大反应较对照组显著升高 (P <0 .0 5) ;间断性 -Gx重力暴露组大鼠基底动脉血管环对KCl的最大反应较悬吊组显著减弱 (P <0 .0 5) ,与对照组无显著差别。结论间断性 -Gx暴露可对抗模拟失重对大鼠脑动脉血管反应性的影响 。
Objective To investigate counteracting effects of intermittent -Gx exposure on changes of responsiveness of basilar artery in tail suspended rats. Method Rats tail suspended for 3 wk were daily subjected to 1 h 1.5 G or 2.6 G centrifugation, simulating -Gx exposure of various G values. Responses of perfused isolated basilar arterial rings to KCl was examined. Result Maximal isometric contractile response to KCl were significantly enhanced in arterial rings isolated from 3 wk tail suspended rats as compared with that from simultaneous control rats (P<0.05). However, maximal isometric contractile responses to KCl of arterial rings isolated from 3 wk tail suspended plus daily -Gx exposure rats were no difference as compared with that from simultaneous control rats, and were significantly decreased (P<0.05) as compared with that from 3 wk tail suspended rats. Conclusion Daily intermittent -Gx exposure as a countermeasure to prevent the effects of simulated weightless on changes in responsiveness of basilar artery from tail suspended rats was valid.
出处
《航天医学与医学工程》
CAS
CSCD
北大核心
2001年第4期244-247,共4页
Space Medicine & Medical Engineering
基金
国家自然科学基金资助项目 (3 980 0 15 7)
全军医药卫生科研基金资助项目 (98Z0 83
0 1Q1 1 4)
关键词
失重模拟
尾悬
站立位
离心
基底动脉
血管反应性
weightlessness simulation
tail suspension
standing
centrifugation
basilar artery
vascular responsiveness
