钛合金粉浆涂塑冠桥材料的生物安全性评价

Biological Assessment of Sintered Titanium Alloy for Dental Crown and Bridge by Means of Slip Casting

目的 评价钛合金粉浆涂塑冠桥材料的生物安全性。方法 采用该材料分别对仓鼠、NIH纯系小鼠和豚鼠进行急性毒性、细胞毒性、致敏性、口腔粘膜刺激性、溶血及微核等项动物试验。结果 钛合金粉浆涂塑冠桥材料的溶血率为 2 .2 1% ,低于 5 % ,说明其有良好的血液相容性。而且 ,该材料无明显的细胞毒性作用 ,也未见任何急性毒性反应 ,对口腔粘膜无刺激性 ,无致敏性 ,微核试验未见潜在致突变性。结论 钛合金粉浆涂塑冠桥材料用于临床具有可靠的生物安全性。

Objective To evaluate the biological safety of sintered titanium alloy for dental crown and bridge, and provide a sound scientific basis for dental clinical practice. Methods A series of tests, including acute toxicity test, cytotoxity test (agar overlay), sensitization test, oral mucous membrane irritation test, haemolysis test and micronucleus test were conducted to examine the dental crown/bridge used titanium alloy which is processed with vacuum sintered powder metallurgy. Results The haemolysis rate of this material was 2.21% (less than 5%), an index of good blood compatibility. Cytotoxic effect was not observed in cell culture, nor was toxic effect observed in mouse toxicity test. Local mucous membrane irritation reaction was not found. No potential mutagenicity of this material was noted. Conclusion Dental crown/bridge used titanium alloy material is of reliable was noted biological safety in dental clinical application.