2型糖尿病患者的胃动力学变化及相关因素探讨

Study on Gastric Motility and Its Relevant Factors in Type 2 Diabetes

目的 探讨糖尿病胃动力学变化及其相关因素。方法 采用半流质核素胃排空试验对 12 9例 2型糖尿病患者的胃动力学进行研究 ,包括病程、血糖水平、Hb Alc、血浆胰岛素、胃动素、胃泌素、胰升糖素、镁离子浓度及 BMI等。结果 12 9例 2型糖尿病患者中 ,胃排空延迟者占 6 2 .0 2 %。而胃动力异常与病程、FPG、2 h PPG、胰岛素、胃动素、Hb Alc及体重指数均有密切关系。结论 糖尿病胃动力异常是诸多因素共同作用的结果 ,早期进行胃排空试验 ,可对本症早期诊断。

Objective In this study radionuclide semi liquid gastric emptying (GE) study was adopted to test the gastric motility in 129 patients with type 2 diabetes. Further study was made to explore the relationship between gastric motility disorder of diabetes and the influential factors. Methods The variables to be measured and analyzed were age, BMI, duration of illness, level of glycemia, HbAlc, plasma insulin, motilin, gastrin, glucagon and Mg 2+ . Results Of the 129 cases, 80 had delayed GE with an occurrence of 62.02%, and there was a close correlation between gastric motility disorder and the duration of illness, BMI, FPG, PPG, serum insulin, motilin levels and HbAlc as well.Conclusion These findings imply that gastric motility disorder of diabetes is influenced by multiple factors. The results also suggest that gastric motiligy disorder is much more common than expected, and radionuclide gastric emptying test is a useful aid for the early detection of this clinical entity.