TSGF检测在恶性肿瘤诊断及疗效观察中的价值

Evaluation of tumor specific growth factor value detection in the diagnosis and treatment of malignant tumors

目的 探讨恶性肿瘤特异性生长因子 (Tumorspecificgrowthfactor ,TSGF)检测在恶性肿瘤诊断及疗效观察中的价值。方法 采用福建新大陆生物技术有限公司提供的TSGF癌症快速检测试剂盒 ,对健康体检组 1 0 2例、良性病变组 71例、恶性肿瘤组 376例血清TSGF含量进行测定。结果 恶性肿瘤组患者血清TSGF含量 [( 6 9.0± 1 2 .8)U/ml]与健康体检组 [( 53.2± 5.4 )U/ml]及良性病变组 [( 59.5± 1 0 .6 )U/ml]相比均有非常显著性差异 (P <0 .0 1 ) ;恶性肿瘤组中经有效治疗后血清TSGF含量 [( 6 1 .9± 1 0 .2 )U/ml]明显低于治疗前 [( 6 9.6± 1 2 .8)U/ml](P <0 .0 1 ) ,而治疗后复发、转移者 ,血清TSGF含量 ( 77.3± 1 5.0U/ml)明显升高 ,阳性检出率达91 .1 %。结论 TSGF对恶性肿瘤的早期筛查和复发转移的监测有重要价值。

Objective To evaluate detecting tumor specific growth factor (TSGF) in the diagnosis and treatment of malignant tumors. Methods Serum TSGF level of 102 healthy people, 376 cases of malignant tumors and 71 patients with benign lesions were measured with TSGF diagnostic kit produced by Fujian New Land Biotechnology (oLTD). Results The average TSGF value of patients with malignant tumors(69.0±12.8 U/ml) was significantly higher than that of the health people(53.2±5.4 U/ml) or patients with benign lesions (59.5±10.6 U/ml), respectively ( P <0.01). After effective treatment, the TSGF level of patients with malignant tumors(61.9±10.2 U/ml) decreased significantly ( P <0.01). However,the TSGF level (77.3±15.0 U/ml) increased remarkably in cases of recurrent or metastatic cancers and the positive rate reached 91.1%. Conclusion TSGF is an important marker for the early screening and monitoring of recurrence or metastasis of malignant tumors.