摘要
目的 :观察软脉胶囊对脑缺血再灌注大鼠的影响。方法 :用结扎大鼠两侧颈总动脉和迷走神经的方法复制脑缺血再灌注模型。观察血液中的NO、6 keto PGF1a、TXB2 含量变化。结果 :软脉胶囊 0 .81g/kg、2 .43g/Kg能升高 6 keto PGF1a、NO含量 ,有降低TXB2 趋势。结论 :软脉胶囊对脑缺血再灌注大鼠有保护作用 ,其作用可能通过抑制血小板聚集和升高NO来实现的。
Objective:To investigate the protective effects of Ruanmai Capsules on cerebral ischemia-reperfuse injury in rats.Methods:A cerebral ischemia-reperfuse model in rats was established by ligaturing bilateral arterial carotis communis and vagus nerve. NO, 6-keto-PGF 1a and TXB 2 in serum were examined. Results: Ruanmai Capsule (0.81g/kg and 2.43g/kg,po) increased the levels of NO, 6-keto-PGF 1a. It also had the tendency to decrease TXB 2 in serum. Conclusions: Ruanmai capsules can alleviate brain injury caused by cerebral ischemia reperfusion. The effect is achieved perhaps by inhibiting platelet aggregation and increasing NO.
出处
《中成药》
CAS
CSCD
北大核心
2001年第5期359-361,共3页
Chinese Traditional Patent Medicine
基金
河北省医药局科技专项基金资助!No .98Z0 3 13
