银杏露镇咳、祛痰及平喘的药效学研究

Pharmacodynamic Studies on Cough-settling, Phlegmdispelling and Panting-calming Actions of Ginkgo Distillate

目的 :观察银杏露的镇咳、祛痰及平喘作用。方法 :采用小鼠氨水引咳法及气管酚红排泌法观察银杏露的镇咳及祛痰作用 ,采用哮喘发作潜伏期及离体气管平滑肌松弛试验观察银杏露的平喘作用。结果 :银杏露能抑制氨水引起的小鼠咳嗽 ,促进小鼠气管酚红排泌 ;对磷酸组胺引起的豚鼠哮喘具有保护作用 ,能明显延长哮喘潜伏期 ;对磷酸组胺引起的豚鼠气管收缩具有抑制作用。结论 :银杏露具有镇咳、祛痰及平喘作用。

Objective:To evaluate the cough-settling, phlegm-dispelling and panting-calming actions of Ginkgo Distillate. Methods: The cough-settling and phlegm-dispelling effects were observed on the ammonia water-induced cough model of mice and phenol red expectoration method. The panting-calming effect was observed by wheezing and panting incubation period and relaxation test of isolated tracheal smooth muscle. Results: Ginkgo Distillate could inhibit mouse cough induced by ammonia water, promote mouse tracheal expectoration induced by phenol red, remit the wheezing and panting induced by histamine phosphate, prolong the wheezing and panting incubation period. It also possessed the inhibition on guinea pig tracheal contraction induced by histamine phosphate. Conclusions: Ginkgo Distillate has the cough-settling, phlegm-dispelling and panting-calming actions.