乳腺癌、胃肠道癌皮肤转移CK18和CK20及CEA的表达

Expression of CK18，CK20 and CEA in cutaneous metastases from breast and gastrointestinal carcinoma

为了探讨CK18和CK20在乳腺癌和胃肠道癌皮肤转移中的表达及意义，对11例乳腺癌与12例胃肠道癌皮肤转移患者CK18、CK20和CEA的表达进行免疫组化观察。所有23例皮肤转移癌CK18和CEA均呈阳性表达，其中5例结直肠癌皮肤转移CK20呈阳性表达。结果提示，CK18和CK20在乳腺癌与胃肠道癌皮肤转移中的表达对临床诊断及鉴别诊断具有一定价值。

In order to study the expression of CK18 and CK20 in cutaneous metastases from breast carcinoma and gastrointestinal carcinoma and its significance，CK18,CK20 and CEA expression by using immunohistochemistry method was observed in metastases from 11 cases of breast carcinoma and 12 cases of cutaneous metastases from gastrointestinal carcinoma. All the 23 cases of metastatic carcinoma of the skin expressed CK18 and CEA, 5 cases of cutaneous metastases from colorectal carcinoma expressed CK20. The results suggest that the expression of CK18 and CK20 has great value in diagnosis and differential diagnosis of cataneous metastases from breast carcinoma and gastrointestinal carcinoma.