531例非淋菌性尿道炎病原体及支原体药敏分析

Etiological examination and mycoplasma antimicrobial susceptibility in 531 patients with nongonococcal urethritis

为探讨非淋球菌性尿道炎(NGU)病原体和耐药情况，应用培养和衣原体抗原快速免疫测定法对NGU患者的尿道(宫颈)分泌物进行检测，同时测定支原体对12种抗生素的耐药情况。结果显示531例NGU患者共培养出806株菌种，其中Uu、Mh、Ct、Cd细菌比例分别为49.50％、21.37％、11.33％、12.43％和5.37％；混合感染率达到33.11％，Uu与Mh、支原体与念珠菌混合感染率分别达到12.78％、7.44％；3种或以上病原体感染率达1.73％。药敏试验显示大部分菌株都产生耐药，特别对四环素、乙酰螺旋霉素、红霉素等。研究表明NGU患者病原体仍以支原体为主，但混合感染情况增多，而且支原体的耐药情况较为严重，给临床治疗带来困难。

In order to study the causative agents and mycoplasma resistant to antibiotics in patients with nongonococcal urethritis(NGU), urethral(or cervical )specimens taken from the patients with NGU were detected by c-c rapid assay and culture, and antimicrobial susceptibility testing of mycoplasma to 12 antibiotics was done at the same time. The result showed that 806 positive specimens were isolated from 531 patients with NGU, the positive rates of U.urealyticum(Uu), M.hominis(Mh), C.trachomatis(Ct), Candida(Cd) and bacteria were 49.50％,21.37％,11.33％,12.43％,5.37％respectively. The mixed infections was in 33.11％of patients, including 12.78％positive for Uu＋Mh, 7.44％for mycolasma＋Cd, and 1.73％for three or more agents. Most strains had resistance to 12 antibiotics, especially to tetracycline, acetospiramycin, erythromycin. Then mycoplasma was the main pathogen of the patients with NGU, but mixed infections were common,and mycoplasma resistant to antibiotics was more severe, which would make trouble in treatment of NGU clinically.