非淋菌性尿道炎患者中单纯疱疹病毒感染的流行病学分析

Epidemiologic study of herpes simplex virus infection in patients with nongonococcal urethritis

为探讨非淋菌性尿道炎(NGU)患者中单纯疱疹病毒(HSV)感染的流行病学特征，用聚合酶链反应(PCR)检测患者尿道或宫颈分泌物中的HSV-2，并对阳性患者用盐酸万乃洛韦(明竹欣)作抗病毒治疗7～10天，作追踪观察。结果发现约20.8％的NGU患者HSV-2阳性，经治疗后HSV-2均转阴性，但仅2例患者同时伴临床症状的消失。女性、性伴数>5、伴其它STDs、病程长及抗生素疗效不佳等特征的NGU患者感染HSV的可能性大。

To determine the epidemiologic characteristics of herpes simplex virus(HSV) infection in patients with nongonococcal urethritis(NGU), by using polymerase chain reaction(PCR) technique, the male urethral and female endocervical swab specimens were detected for HSV-2. Those HSV-2 positive patients were treated by valaciclovir for 7～10 days, and followed up. The results indicated that about 20.8％of NGU patients were positive for HSV-2, and HSV-2 changed to negative in all patients after treatment, but the clinical symptoms disappeared only in two patients. The possibility of HSV-2 infection was greater in those patients who were female, with more than 5 sexual partners and longer duration of illness,complicated by other STDs, and not improved in the treatment with antibiotics.