0.2%酒石酸溴莫尼定滴眼液的降眼压作用

The effects of Alphagan eyedrops to lower intraocular pressure

目的 :证实 ( 0 .2 %酒石酸溴莫尼定 Brimonidine Tartrate)阿法根 ,滴眼液治疗原发开角型青光眼和高眼压症的降眼压效果及安全性。方法 :选择 12 6例原发性开角型青光眼或高眼压症患者 ,随机分成试验组 (阿法根 )和对照组 ( 0 .5 %噻吗心安 )。两组均每日点药两次 (早 8点和晚 8点 ) ,每次一滴。将点第一滴药后 2小时的眼压及连续点药后 2周、 4周的眼压与基线眼压进行比较研究 ,同时观察血压、心率等全身及局部副作用。结果 :试验组点药前平均眼压为 2 5 .9± 3 .2 mm Hg,点一滴药后 2小时平均眼压为 17.7± 3 .8mm Hg (下降 3 1.7% ) ,连续点药 2周平均眼压为 16.2± 3 .0 mm Hg,(下降 3 7.5 % ) ,4周平均眼压为 16.2± 3 .2 mm Hg (下降 3 7.5 % ) ;对照组点药前平均眼压为 2 5 .5± 2 .5 mm Hg,点一滴药后 2小时平均眼压为 18.3± 3 .7mm Hg(下降 2 8.2 % ) ,连续点药 2周平均眼压为 17.2± 2 .8mm Hg (下降3 2 .5 % ) ,4周平均眼压为 17.5± 3 .4 mm Hg(下降 3 1.3 % ) ,经统计学处理两组之间降眼压效果无显著性差异。试验组无明显的局部和全身不良反应发生 ,对照组则对血压和心率有一定的影响。结论 :阿法根与 0 .5 %噻吗心安每日两次点药相比 ,降眼压效果相似 ,但全身和局部副作用少 ,可以作为?

Objective: To evaluate the ocular hypotensive efficacy and safety of Alphagan (Brimonidine Tartrate 0.2%) to treat primary open-angle glaucoma (POAG) or ocular hypertension. Methods: 126 patients with POAG or ocular hypertension were randomly divided into the trial (Alphagan) group or the control (Timolol, 0. 5%) group. One drop of Alphagan or Timolol was instilled to patients twice daily (at 8:00 AM and 8:00 PM). Intraocular pressure (IOP) at hours 2 after instilling the first dose, and weeks 2 and 4 after sustained instilling were compared with the baseline. On the other hand, systematic and local adverse effects were also observed. Results: In the trial group, the mean IOP was 25.9 ( 3.2 mmHg at baseline, 17.7 ( 3.8 mmHg (decreased 31.7%) at hours 2 after instilling the first dose, 16.2 ( 3.0 mmHg (decreased 37.5 %) at weeks 2 after sustained instilling, 16.2 (3. 2 mmHg (decreased 37. 5%) at weeks 4 after sustained instilling, respectively. In the control group, the mean IOP was 25.5 ( 2.5 mmHg, 18.3 ( 3.7 mmHg (decreased 28.2%), 17.2 ( 2.8 mmHg (decreased 32.5%), 17.5 ( 3.4 mmHg (decreased 31.3 %), respectively. The difference between two groups in ocular hypotensive efficacy was not significant. No systematic and local adverse effects were observed in the trial group, but some changes in blood pressure and heart rate were observed in the control group. Conclusions: Alphagan instilling twice daily showed ocular hypotensive efficacy similar to Timolol 0.5%, and a relatively low rate of systematic and local adverse effects. Alphagan could he taken as a main choice during glaucoma drug administration.