丙戊酸钠治疗癫痫的血药浓度监测

Monitoring of serum drug concentration in epileptic patients with sodium valproate monotherapy

目的：研究丙戊酸钠治疗癫痫的疗效与血药浓度的关系。方法：以荧光偏振免疫法测定135例癫痫患者丙戊酸钠血药浓度。结果：丙戊酸钠单一用药的总有效率为80.6%，血药浓度在40～100 μg ·ml-1范围内，67.4%的病例显效。效差和无效的病例中，76.7%血药浓度＜ 40 μg·ml-1。35例在监测血药浓度后经调整剂量或间隔改善了疗效。结论：血药浓度监测对丙戊酸钠治疗癫痫的个体化用药具有重要意义。

：OBJECTIVE To study the relationship between effect of control of epilepsy seizures and the serum concentration of sodium valproate (VPA) in the patients receiving VPA monotherapy. METHODS Two hundred and twenty-two VPA serum level measurement s were made in 135 epileptic patiens by using the method of fluorescence polariz ation immunoassay (FPIA). RESULTS Total effective rate of VPA monotherapy was 80.6%.W ithin the normally proposed therapeutic range (40～100 μg·ml-1)，67.4% of cases had a decrease more than 75% in seizure frequency.Badcontrol seizure was found in 76.8% of the cases with the serum concentration of VPA lower t han 40 μg·ml-1.35 patients had an improved seizure control by adjusted d osage and interval based on the serum concentration of VPA. CONCLUSIONS This study indicates that it is important for epile ptic patients wih VPA monotherapy individually to monitor serum drug concentrati on.