多灶性膀胱癌不同瘤体间p21、p53及EMA的表达

The expressions of p21,p53 and EMA in various tumors of multifocal bladder cancers

目的 探讨多灶性膀胱癌的发生机制。 方法 运用免疫组化法检测 5例多灶性膀胱癌 2 0个不同瘤体中 p2 1、p5 3和EMA的表达。 结果 5例患者中有 4例散在肿瘤标本 p2 1及 p5 3表达一致 ,5例EMA表达一致。

Objective To study the mechanism of occurrence of the multifocal bladder cancers. Methods The expressions of p21,p53 and EMA in twenty specimens from 5 cases of multifocal bladder cancers were studied by means of immunohistochemistry. Results In 4 of 5 cases, the expressions of p21 and p53 were correspondent in scattering specimens from the same patient. In all the 5 cases, the expressions of EMA were correspondent in scattering specimens from the same patient. Conclusions Multifocal bladder cancer may originate from the same monocolone.