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白细胞介素-13的研究进展 被引量：4

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摘要 IL-13是由活化的T细胞分泌产生的一种细胞因子 ,分子量约为 10 17kD。人IL 13基因全长 4.6kb ,定位于染色体5 q2 3.31区 ,IL 13生物学功能主要是抑制单核细胞释放炎性细胞因子和化学因子 ,诱导B细胞增殖和分化 ,促进IgE合成 ,促进内皮细胞上表达某些粘附分子及抑制HIV 1病毒复制。IL 13在临床上与抗炎症、过敏性疾病治疗及对抗蠕虫感染等有关。它通过与细胞膜上特异的IL 13受体结合 ,激活JAK激酶途径 ,从而发挥其生物学功能。
作者 李鸿钧 苏婷 孙茂盛
机构地区 中国医学科学院中国协和医科大学医学生物学研究所
出处 《国外医学（临床生物化学与检验学分册）》 2001年第4期187-188,共2页 Foreign Medical Sciences(section of Clinical Biochemistry and Laboratory Medicine
关键词 IL-13 基因 生物学功能 IL-13受体
分类号 Q26 [生物学—细胞生物学]
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参考文献10

  • 1Mckenzie ANJ,Culpepper JA,de Wall Malefyt R,et al.Interleukin 13, a T-cell-derived cytokine that regulates human monocyte and B-cell function[].Proceedings of the National Academy of Sciences of the United States of America.1993
  • 2de Vries JE,Zurawski G.Immunoregulatory properties of IL13: its potential role in atopic disease[].International Archives of Allergy and Immunology.1995
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  • 6Montaner LJ,Bailer RT,Gotrdon S,et al.IL-13 acts on macrophjages to block the completion of reverse transcription,inhibit virus prodution, and reduce virus infectivity[].Journal of Leukocyte Biology.1997
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同被引文献32

  • 1王业军,张秋业.过敏性紫癜研究进展[J].齐鲁医学杂志,2005,20(5):457-458. 被引量：18
  • 2Williams HC, Burney PG, Hay RD, et al. The U. K.Working party's diagnostic criteria for atopic dermatitis. I.Derivation of a minimun set of discrimiators for atopie dermatitis[J]. Br J Dermatol,1994,131:383- 396.
  • 3吴瑞萍,胡亚美,江载芳.实用儿科学[M].第6版.北京:人民卫生出版社,1997,1084.
  • 4MATSUMTO K. Interleukin-13 inhibits cytokine secretion by blood monocytes from patients with IgA nephropathy[J]. Nephron, 1997,75:295-302.
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  • 6WEILER M, ROGASHEV B, EINBINDER T, et al. Interleukin-15,a leukocyte activator and growth factor, is produced by cortical cubular epithelial cells[J]. J Am Soc Nephrol, 1998,9:1194-1201.
  • 7WEILER M, ROGASHEV B,EINBINDER T, et al. Interleukin-15,a leukocyte activator and growth factor, is produced by cortical tubular epithelial cells[J]. J Am Soc Nephral, 1998,9:1194-1201.
  • 8MATSUMOTO D, OHI H, KANMATSUSE K, et al. Effects of interleukin-15 on vascular permeability factor release by PBMC in normal subject and in patients with minimalchangd nephritic syndrome[J]. Nephron, 1999,82:32-38.
  • 9Maleft RW, Figdor CG, Huijbens R. et al. Effects of IL-13 onphenotype, cytokine production. and cytotoxic function of humanmonocytes[J]. J Immunol, 1993, 151(6): 6370-6378.
  • 10Minty A, Chalon P, Edrolg JM, et al. Interleukin-13 is anewhuman lymphokine regulating inflammatory and response [J].Nature, 1993, 362(2): 248-250..

引证文献4

二级引证文献5

国外医学（临床生物化学与检验学分册）
2001年 第4期

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