摘要
血小板抗体的检测对免疫性血小板减少的诊断有重要意义。近年来对血小板抗体的本质和靶抗原的研究日益深入 ,新的检测手段也日益发展。流式细胞仪检测血小板相关抗体和血小板膜糖蛋白已成为特发性血小板减少性紫癜的一个新的诊断方法。本文就近年来上述方面的研究进展作一综述。
出处
《国外医学(临床生物化学与检验学分册)》
2001年第4期207-208,共2页
Foreign Medical Sciences(section of Clinical Biochemistry and Laboratory Medicine
参考文献10
-
1Warner MN,Moore JC,Warkentin TE,et al.A prospective study of protein-specific assays used to investigate idiopathic thrombocytopenia purpura[].British Journal of Haematology.1999
-
2Dahlla S.Micromethod for demonstrating increased platelet surface immunoglobulin G: findings in acute, chronic, and human immunodeficiency virus-1-related immunologic thrombocytopenias[].American Journal of Hematology.1990
-
3Kiefel V,Santoso S,Kaufmann E,et al.Auto antibodies against platelet glycoprotein Ib/IX: a frequent findings in autoimmune thrombocytopenic purpura[].British Journal of Haematology.1991
-
4Macchi L,Clofent-Sanche G,Morit G,et al.PAICA: a method for characterizing platelet-associated antibodies-its application to the study of idiopathic thrombocytopenia purpura and to the detection of platelet-bound c7E3[].Thrombosis and Haemostasis.1996
-
5Melinda CH,Bruce HP.Detection of platelet-associated immunoglobulin in immune thrombocytopenia by flow cytomery[].Diagnostic and Clinical Immunology.1988
-
6Mizumoto Y.Flow cytometric analysis of anti-platelet antibodies in patients with chronic thrombocytopenia purpura(ITP)using acid-treated, formalin-fixed platelets[].American Journal of Hematology.1991
-
7Rao GH,Peller JD,White JG.Influence of ionized calcium on thrombin-induced down regulation of GPⅠb/IX receptors on human platelets[].Thrombosis Research.1997
-
8Biglino P,Perutelli P,Mori PG,et al.Platelet antibody detection in pediatric immune thrombocytopenic purpura: evaluation of three screening methods[].Vox Sanguinis.1997
-
9Visentin GP,Wofmeyer PJ,Aster RH,et al.Detection of drugdependent, platelet-reactive antibodies by antigen-capture ELISA and flow cytometry[].Transfusion.1990
-
10Raife TJ,Olson JD,Lentz SR,et al.Platelet antibody testing in idiopathic thrombocytopenic purpura[].Blood.1997
同被引文献20
-
1Rozman P. Platelet antigens ,The role of human platelet al. loantigens (HPA) in blood transfusion and transplantation [J]. Transpl Immunol, 2002,10 (2-3) : 165-181.
-
2Hou M, Stockelberg D, Kutti J, et al. Antibodies against platelet GPIb/IX, GP Ⅱ b/Ⅲ a, and other platelet antigens in chronic idiopathic thrombocy-topenic purpura [J ]. Eur J Haematol, 1905,55 (5) : 307-314.
-
3Ichiyoshi Y, Zhou M,Casali P. A human anti-insulin IgG autoantibody apparently arises through clonal selection from an insulin-specific"germ-lin "natural antibody template. Analysis by V gene segment reassortment and site-directed mutagenesis [J]. J Immunol,1995,154(1):226-238.
-
4Horn IR, Nielsen MJ, Madsen M,et al. Generation of a haptoglobin hemoglobin complex-specific Fab antibody blocking the binding of the complex to CD163[J]. Eur J Haematol,2003,71(4) :289- 293.
-
5Sanna PP. Expression of antibody Fab fragments and whole immunoglobulin in mammalian cells[J]. Methods Mol Bio1,2002,178 : 389-395.
-
6Rondot S, Koch J, Breltling F ,et al. A helper phage to improve single-chain antibody presentation in phage display[J]. Nat Biotechnol,2001,19(1 ) :. 75-78.
-
7Barbas CF,Kang AS,Lerner RA. Assembly of combinatorial antibody libraries on phage surfaces:the gene Ⅲ site[J]. Proc Natl Acad Sci USA01991,88(18):7978-7982.
-
8Winter G, Griffiths AD. Making antibodies by phage display technology [J]. Annu Rev Immunol, 1994,12.433-455.
-
9Jacobin MJ ,Laroche-Traineau J ,Little M ,et al. Human IgG monoclonal anti-alpha Ⅱ b beta (3)-binding fragments derived from immunized donors using phage display[J]. Immunol,2002,168(4) :2035-2045.
-
10Panzer S, Szamait S, Bodeker RH, et al. Platelet associated immunoglobulin IgG, IgM, IgA and complement C3 in immune and nonimmune thrombocytopenic disor- ders[J].Am JH ematol,1986,23(2):89-99.
引证文献3
-
1任霞,赵敬湘,周虹,王字玲.抗血小板人源噬菌体抗体库的构建和初步筛选[J].临床输血与检验,2006,8(1):26-30. 被引量:1
-
2吴蓓倩,朱萍,牛强,陈字,谢毅.血小板自身抗体的流式细胞检测与意义[J].医学研究杂志,2008,37(11):79-80. 被引量:6
-
3王朋,林菲菲,李金美,陈佳琦.PAIgG的检测在血小板减少症中的应用及意义[J].现代实用医学,2012,24(10):1162-1163. 被引量:1
二级引证文献8
-
1李执如,廉维,宿兰.血小板抗原多态性和配型输注[J].现代临床医学,2007,33(2):143-145. 被引量:2
-
2薛磊,朱薇波,吴竞生,蔡晓燕,刘欣,韩永胜,杨会志,郑昌成,李庆.流式细胞术检测血小板相关抗体和CD 61诊断特发性血小板减少性紫癜[J].血栓与止血学,2011,17(1):8-12. 被引量:20
-
3王贞,刘艳,杨冬,马晓露,刘贺,袁宏.血小板计数、血小板抗体、骨髓细胞学对血小板减少鉴别诊断的意义[J].国际检验医学杂志,2011,32(5):606-608. 被引量:13
-
4宁建英,谷强,盛磊.B淋巴细胞激活因子与儿童特发性血小板减少性紫癜的相关性[J].中国皮肤性病学杂志,2013,27(10):1005-1007.
-
5仲玉强,王清.B淋巴细胞激活因子表达水平在儿童特发性血小板减少性紫癜诊断及预后判断中的意义[J].临床儿科杂志,2014,32(10):924-927. 被引量:14
-
6刘明伟,王飞.流式细胞术检测血小板相关抗体在特发性血小板减少性紫癜诊治中的意义[J].现代医药卫生,2015,31(5):726-727. 被引量:4
-
7周灵芝,高顺利,游诚.儿童特发性血小板减少性紫癜血清B淋巴细胞激活因子表达分析[J].中国皮肤性病学杂志,2015,29(6):593-594. 被引量:13
-
8陈佳琦,曲春生,王朋,吴伟平.幽门螺杆菌感染与血小板相关参数分析[J].检验医学,2015,30(10):991-992.
-
1周平,朱晓琴.腹腔镜脾切除术治疗特发性血小板减少性紫癜的护理[J].现代医药卫生,2009,25(8):1150-1152. 被引量:1
-
2郭桃.67例特发性血小板减少性紫癜患者的护理干预[J].中国保健营养(下半月),2013,0(7):1847-1848. 被引量:1
-
3庄宇,谭志明.干燥综合征合并难治性免疫性血小板减少1例[J].广东医学,2013,34(13):2096-2096.
-
4孙德华,裘宇容.网织血小板检测在血液系统疾病诊断中的初步应用[J].热带医学杂志,2008,8(6):581-583. 被引量:5
-
5李建萍.静注大剂量丙种球蛋白治疗淋巴瘤合并免疫性血小板减少的护理[J].广西医学,2003,25(8):1572-1573.
-
6杨燕澜,武宇辉,尹艳,陈丽,叶惠英,严建花,王磊.临床护理路径在儿童特发性血小板减少性紫癜患者中的应用[J].中国煤炭工业医学杂志,2013,16(10):1725-1727. 被引量:4
-
7徐雪忠.5例重度特发性血小板减少性紫瘢患儿的护理[J].天津护理,2006,14(5):268-269.
-
8叶兵.头孢曲松引起免疫性血小板减少和溶血性贫血:血小板和红细胞上的靶部位特点[J].国外医学(输血及血液学分册),2005,28(1):91-91. 被引量:2
-
9梁晓浏,王保龙,上官志敏,叶书来,陈家萍,廖艳秋,朱梅红,姚萍.特发性血小板减少性紫癜与HPA等位基因相关性研究[J].中国输血杂志,2009,22(3):207-210. 被引量:3
-
10刘利梅,李晓红,潘家华.以皮肤出血点为主要表现的男性狼疮性肾炎1例[J].临床肺科杂志,2010,15(2):289-289.