前列腺素E_1脂微体载体制剂治疗视网膜静脉阻塞

Efficacy of retinal vein occlusion treated with prostaglandin E_1 incorporated in lipid micropheres

目的 :观察前列腺素E1脂微体载体在视网膜静脉阻塞症 (RVO)中的临床疗效。方法 :比较视网膜静脉阻塞症病例应用前列腺素E1脂微体载体制剂 (治疗组 )与对照组在观察期内的视力改善情况。结果 :随访观察 1～ 6月 ,治疗组 2 1例患者治疗后最终视力≥ 0 .5者有 16例 ,有效率为 76 .2 % ;对照组 17例患者中治疗最终视力≥ 0 .5者有 6例 ,有效率为 34 .7% ,两组疗效差异有显著性意义 (χ2 =6 .45 ,P <0 .0 5 )。治疗组中患者视力得以提高者有 17例 ,对照组中有 6例 ,改善率分别为 81.0 %与 41.2 % ,差异有显著性意义 (χ2 =6 .41,P <0 .0 5 )。结论 :前列腺素E1脂微体载体制剂对治疗视网膜静脉阻塞症是有效的。

Objective:To observe the efficacy of prostaglandin E 1 incorporated in lipid micropheres for the treatment of retinal vein occlusion.Methods:The improvement in the visual acuity of patients who had been treated for retinal vein occlusion treated with prostaglandin E 1 incorporated in lipid micropheres was compared with that of a control group during the duration of the treatment period.Results:After 1～6 months of follow up, visual acuity for the 16 patients in the treatment group was ≥0.5 with an effective rate of 76.2% while visual acuity for the 6 patients in the control group was ≥0.5 with an effective rate of 34.7% (χ 2=6.45;P=0.05). The percentages of improvement in vision were 81.0% and 41.2% in the treatment and control groups, respectively (χ 2=6.41;P<0.05).Conclusion:Prostaglandin E 1 incorporated in lipid micropheres is effective for treating retinal vein occlusion.