全反式维甲酸诱导分化治疗对胃癌患者免疫功能的影响

EFFECT OF INDUCING DIFFERENATION OF ALL TRANS RETINOIC ACID ON IMMUNITY OF PATIENTS WITH GASTRIC CARCINOMA

目的观察全反式维甲酸（ａｌｌ ｔｒａｎｓ ｒｅｔｉｎｏｉｃ ａｃｉｄ， ＡＴＲＡ）诱导分化治疗对胃癌患者免疫功能的影响。方法对５６例胃癌患者进行诱导分化治疗，测定外周血Ｔ淋巴细胞亚群（Ｔ－ＬＳ）和血清白细胞介素Ⅱ受体（ｓＩＬ－２Ｒ）水平。结果根治性手术组： ＣＤ３、ＣＤ４细胞数及 ＣＤ４／ＣＤ８比值较对照组明显增高，ｓＩＬ－２Ｒ水平明显降低；经 ＡＴＲＡ治疗后，上述指标接近正常对照组；未手术或未根治性手术组：经ＡＴＲＡ治疗后，ＣＤ３、ＣＤ４细胞数及ＣＤ４／ＣＤ８比值也明显增高，ｓＩＬ－２Ｒ水平明显降低。结论ＡＴＲＡ诱导分化治疗能有效提高胃癌患者的免疫功能。

Objective To evaluate the effect of inducing differenation of all trans retinoic acid (ATRA) on immunologic function of patients with gastric cancer. Methods T-lymphocyte subsets(T-Ls) and interleukin-2 receptor(sIL-2R) of 56 patients with gastric cancer after treatment of ATRA were studied. Results in radical gastric cancer resection group. the serum CD3 ,CD4 and CD4 /CD8, rate were higher and sIL-2R were lower than those in the control group, after treatment of ATRA, CD3 ,CD4, and CD4 /CD8 rate and sIL-2R were as high as those in the control group. In the non-operative or palliative gastric resection group, CD3,CD4 and CD4 /CD8 rates were increased markedly and the serum slL-2R was decreased significantly than those in the control group. Conclusion ATRA inducing differenation can improve the immunity of the patients with gastric cancer.