细胞凋亡和血管病变

CELL APOPTOSIS AND VASCULAR DISEASE

目的探讨细胞凋亡与血管病变的关系。方法就细胞凋亡的概念、特征、基因调控、信号传导及其与血管病变的关系作一综述。结果细胞因子、辐射、氧自由基等可诱导血管内皮细胞凋亡，导致血管损伤；而平滑肌细胞凋亡与动脉粥样硬化和血管成形术后再狭窄密切相关。结论细胞凋亡异常与血管病变密切相关。

Objective To study the relationship between cell apoptosis and vascular disease. Methods The paper reviewed the concept, character, gene control and signal transduction of apoptosis associated with vascular disease. Results Cytokine, radiation could induce apoptosis of endothelial cells, and caused vascular damage. The apoptosis of smooth muscle cells was related to the atherosclerosis and restenosis of vessels. Conclusion Cells apoptosis is related to vascular disease significantly.