血管内皮生长因子与肿瘤血管生成

VASCULAR ENDOTHELIAL GROWTH FACTOR AND TUMOR ANGIOGENESIS

目的评价血管内皮生长因子（ＶＥＧＦ）对肿瘤血管生成的影响及其在肿瘤治疗中的应用。方法通过对近年来血管内皮生长因子促进肿瘤血管生成方面的相关文献回顾，总结ＶＥＧＦ研究的进展，介绍抗血管生成治疗在肿瘤生物治疗中的作用。结果血管生成在肿瘤生长中的重要地位已经被证实。在众多的促进肿瘤血管生成因素中，ＶＥＧＦ起到最基础和最关键的作用。针对ＶＥＧＦ的抗肿瘤血管生成的治疗已取得了很大进展，包括应用ＶＥＧＦ抑制剂、腺病毒介导的基因治疗等。结论ＶＥＧＦ是主要的促进肿瘤血管生成的物质，针对ＶＥＧＦ的抗血管生成治疗可能给恶性肿瘤的治疗带来新的契机。

Objective To evaluate the effect of vascular endothelial growth factor (VEGF) on tumor angiogenesis, and its usage in tumor therapy. Methods The recent literatures about VEGF and angiogenesis were reviewed and analyzed. The advances of VEGF study were summarized. The effects of anti-angiogenesis in tumor biological therapy were introduced. Results Angiogenesis had been identified as an important factor for promoting tumor growth. VEGF was a basic and pivotal factor in tumor angiogenesis. The anti-angiogenesis treatments aimed at VEGF, including the applications of VEGF inhibitor and gene therapy of adenovirus medium, had got great progress. Conclusion VEGF is a leading factor of tumor angiogenesis, the anti-angiogenesis therapy aimed at VEGF has probably provided a new chance to malignant tumor treatment.