β-七叶皂甙钠在烧伤早期的应用

Clinical Application of Beta-Aescine in the Early Postburn Stage

目的 探讨β－七叶皂甙钠在烧伤早期的应用价值。方法选择１９９７年３月～１９９９年７月，烧伤总面积≥１０％的３～１２岁小儿和烧伤总面积≥３０％的成人，应用β－七叶皂甙钠且休克期度过平稳者作为研究对象，共６０例。观察清创后浅Ⅱ°创面２４ｈ完全湿透的纱布层数和肿胀完全消退的时间以及休克期补液量等变化。结果β七叶皂甙钠应用后，创面渗出少，消肿快，休克期第一个２４ｈ胶体的补给量减少，而且没有副作用。结论β－七叶皂甙钠具有显著的抗渗出消肿作用，适合于烧伤早期应用。

Objective :To investigate the value of beta-aescine applied in the early postburn stage. Methods From March 1997 to July 1999,60 cases were selected which survived the shock period reposefully and were subjected to the treatment with beta-aescine were studied, including 27 children with burns larger than 10 % TBSA and 33 adults with burns larger than 30% TBSA. The strata of the drenched gauze on the superficial second degree wound 24 hours after the debridement were recorded. The detumescence time of the superficial second degree wound and the fluid resuscitation were also observed. Results Beta-aescine was found to be useful due to reduced wound exudation, enhanced detumescence and reduced colloid capacity during the first 24 hours postburn without sigificant side-effects. Conclusion Due to its marked anti-exudative and detumescent effects, betaaescine is recommended for the early postburn stage.