阴道内放置PGE_2用于足月妊娠引产351例疗效观察

Observation on Effectiveness of Prostaglandin E2 Vaginal Insert For Induction of Labour

目的 比较 PGE2 阴道栓剂及催产素静滴引产的效果。方法 将 5 85例同样条件孕妇 ,随机分两组 ,分别给PGE2 阴道栓剂和催产素静脉滴注引产。结果 前列腺素组及催产素组引产成功率分别为 96 .3%和 79.92 % ;临产发动时间及总产程分别为 (2 .70± 0 .6 3) h,(3.0 1± 3.41) h和 (3.91± 0 .71) h,(6 .0 3± 3.5 0 ) h;剖宫产率分别为6 .8%和 18.18% (P<0 .0 1) ,有显著差异。结论 PGE2 栓剂用于足月妊娠引产效果显著、安全、方便 ,对促宫颈成熟意义重要 ,可缩短住院天数 ,减少住院费用。

Objective\ To compare the effectiveness of labour induction by using either prostaglandin E2 vaginal gel, or intravenous drip of oxytocin. Methods\ 585 hospitalized patients at ≥37 weeks requiring labour induction and having the same condition were randomly divided into two groups and given prostaglandin E2 vaginal gel (the study group ) and oxytocin intravenous drip(the control group) respectively to induce labour. Results\ Success rate of prostaglandin E2 in induction of labour was 96.3%,signifcantly higher than that of oxytocin(79.92%)(P<0.01).The interval between administration of prostaglandin E2 and onset of labour and the duration of labour were 2.7±0.63 hours and 3.01±3.41hours, respectively, wherease those of the control group were 3.91±0.71 hours and 6.03±3.50 hours respectively(P<0.01), with significant difference found between the two groups. Cesarean section rate in the study group was 6.8%, signicantly lower than that in the control group(18.18%,P<0.01). Mean birth weight and incidence of neonatal asphyxia in the two groups were similar (P>0.05) .Conclusion\ Administration of prostaglandin E2 vaginal gel in induction of term pregnancy appeared to be safe, effective and convenient and , especially, the effect of prostaglandin E2 for promoting cervical ripening was most significant. The use of prostaglandin E2 gel would result in shortened hospitalization and less expense.