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肿瘤病人外周血DNA检测的意义 被引量：3

Significance of plasma or serum tumor DNA detection in patients with cancer
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摘要 肿瘤病人血循环中DNA的量较一般人明显增多 ,而且从中可检测到肿瘤相关基因的特征性改变 ,可用于协助诊断 ,并作为预测预后及疗效观察的指标 。
作者 陈建芝 张振书
机构地区 解放军 第一军医大学南方医院消化内科
出处 《国外医学（肿瘤学分册）》 2001年第4期268-270,共3页 Foreign Medical Sciences (Cancer Section)
关键词 DNA 肿瘤血清学 肿瘤诊断学 癌基因 畸变
分类号 R730.4 [医药卫生—肿瘤]
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参考文献10

  • 1Leon SA,Shapiro B,Sklaroff DM,et al.Free DNA in the serum of cancer patients and the effect of therapy[].Cancer Research.1977
  • 2Mayall F,Jacobson G,Wilkins R,et al.Mutations of p53 gene can be detected in the plasma of patients with large bowel carcinoma[].Journal of Clinical Pathology.1998
  • 3Chen Xq,Stroun M,Magnenat JL,et al.Microsatellite alterations in plasma DNA of small cell lung cancer patients[].Nature Medicine.1996
  • 4Wong IH,Lo YM,Zhang J,et al.Detection of aberrant P16 methylation in the plasma and serum of liver cancer patients[].Cancer Research.1999
  • 5Anker P,Lefort F,Vasioukhin V,et al.K-ras mutations are found in DNA extracted from the plasma of patients with colorectal cancer[].Gastroenterology.1997
  • 6Castells A,Puig P,Mora J,et al.K-ras mutations in DNA extracted from the plasma of patients with pancreatic carcinoma: diagnostic utility and prognostic significance[].Journal of Clinical Oncology.1999
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  • 9Giacona MB,Ruben GC,Iczkowski KA,et al.Cell-free DNA in human blood plasma: length measurements in patients with pancreatic cancer and healthy controls[].Pancreas.1998
  • 10Kink GD,Camus Randon AM,Mendy M,et al.Ser-249 p53 Mutations in plasma DNA of patient with hepatocellular carcinoma from The Gambin[].Journal of the National Cancer Institute.2000

同被引文献18

  • 1任宁,钦伦秀.外周血DNA及其遗传学改变与肿瘤转移复发[J].实用肿瘤杂志,2005,20(4):283-285. 被引量：2
  • 2Sheehana M, Kallakuryb VE, Sheehana E, et al. Smad4 protein expression correlates with grade, stage, and DNA ploidy in prostatic adenocarcinomas. Hum Pathol, 2005,36:1204-1209.
  • 3Maounis NF, Chorti M, Apostolakis E, et al. Prognostic impact of Deoxyribonucleic acid (DNA) image analysis cytometry and immunohistochemical expression of Ki67 in surgically resected non-small cell lung cancers. Cancer Detect Prey, 2006,30:507-514.
  • 4Korabiowska M, Cordon-Cardo C, Buschmann N, et al.Comparison of DNA ploidy status and DNA ploidy-related parameters in malignant melanoma tissue microarrays and full sections. Hum Pathol, 2004,35:887-891.
  • 5Fizazi K, Morat L, Chanveinc L, et al. High detection rate of circulating tumor cells in blood of patients with prostate cancer using telomerase activity. Ann Oncol, 2007,18:518-521.
  • 6Yao F, Guo JM, Xu CF, et al. Detecting AFP mRNA in peripheral blood of the patients with hepatocellular carcinoma, liver cirrhosis and hepatitis. Clin Chim Acta,2005,361(1-2):119-127.
  • 7Coon PK, Boos CJ, Stonelake PS, et al. Detection and quantification of mature circulating endothelial cells using flow cytometry and immunomagnetic beads:a methodological comparison. Thromb Haemost, 2006,96:45-52.
  • 8Guo J, Xiao B, Jin Z, et al. Detection of cytokeratin 20 mRNA in the peripheral blood of patients with colorectal cancer by immunomagnetic bead enrichment and real-time reverse transcriptase-polymeras chain reaction. J Gastroenterol Hepatol, 2005,20:1279-1284.
  • 9Kashima K, Nanashima A, Yasutake T, et al. Decrease of telomeres and increase of interstitial telomeric sites in chromosomes of short-term cultured gastric carcinoma cells detected by fluorescence in situ hybridization. Anticancer Res, 2006,26(4B):2849-2855.
  • 10Kumar V, Varma N, Varma S, et al. Flow cytometric analysis of DNA indices, expression of p53 and multidrug resistance genes in multiple myeloma patients. Anal Quant Cytol Histol, 2004,26:271-277.

引证文献3

二级引证文献6

国外医学（肿瘤学分册）
2001年 第4期

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