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胰岛素抵抗的分子生物学机制 被引量：5

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摘要 本文根据胰岛素的作用环节,从受体前水平、受体水平、和受体后水平简述了有关胰岛素抵抗发生机制方面的研究进展。
作者 郭启煜
机构地区 海军总医院
出处 《国外医学（老年医学分册）》 2001年第4期145-148,共4页 Foreign Medical Sciences(Geriatrics)
关键词 胰岛素 胰岛素受体 胰岛素抵抗 病因 发病机制 分子生物学
分类号 R587.1 [医药卫生—内分泌]
  • 相关文献

参考文献10

  • 1[1]Groop LC. Insulin resistance: the fundamental trigger of type 2 diabetes. Obesity & Metabolism, 1999; 1: 2～9
  • 2[2]Olefsky JM, Nolan JJ. Insulin resistance and non-insulin-dependent diabetes mellitus: celluar and molecular mechanisms. Am J Clin Nutr, 1995; 61(4 suppl): 980s
  • 3[3]Accili D. Molecular defects of the insulin receptor gene. Diabetes Metab Rev, 1995; 11:47
  • 4[4]Taylor SI, Accili D, Haft CR et al. Mechanisms of hormone resistance: lessons from insulin-resistant patients. Acta Paediatr, 1994; 399(suppl): 95～104
  • 5[5]Maddux BA, Goldfine ID. Membrane glycoprotein PC-1 in hibition of insulin receptor function occurs via direct interaction with the receptor alphasubunit. Diabetes, 2000; 49(1): 13～19
  • 6[6]Kahn CR. Causes of insulin resistance. Nature, 1995; 373: 384～385
  • 7[7]Brunetti A, Brunetti L, Foti D et al. Human diabetes associated with defects in nuclear regulatory proteins for the insulin receptor gene. J Clin Invest, 1996, 97: 258～262
  • 8[8]Pederson O. Genetics of insulin resistance.Exp Clin Endocrinol Diabetes, 1999; 107(2): 113～118
  • 9[9]Zorzano A, Munoz P, Camps M et al. Insulin-induced redistribution of GLUT4 Glucose carriers in the muscle fiber. Diabetes, 1996; 45(Suppl 1): S70～S73
  • 10[10]Laakso M, Malkki M, Deeb SS. Amino acid substitutions in hexokinase Ⅱ amony patients with NIDDM. Diabetes, 1995; 44(3): 330～334

同被引文献59

  • 1Le Marchand - Brustel Y. Molecular mechanisms of insulin action in normal and inculin - resistant states. Exp Clin Endocrinol Diabetes 1999,107(2):111- 112.
  • 2Kenneth Cusi. Inmdin resistance differentially affects the PI3 - Kinase-and MAP Kinase - mediated signaling in human muscle. The Journal of Clinical investigation 2000,105(3) :311.
  • 3Dela F, et al. GLUT4 and irmdin receptor binding and kinase activity in trained human muscle. J Physiol. 1993,469:615.
  • 4Polly A. Hansen. increased GLUT - 4 translocation modiates enhanced insulin sensitivity of rmiscle glucose transport after exercise . (Rapid Publication ).
  • 5Gulve EA, Spina RJ. Effect of 7 - 10 days of cycle ergometer on ercise onskeletal muscle GLUT4 protein content . J Appl Physiol 1995,79:1562-1566.
  • 6Joseph A. Houmard, Effect of short - term exercise training on insulin -stimulated PI 3 - kinase activity in human skeletal muscle. Am J Physiol Endocrinol Metab 1999,277: E1055- E1060.
  • 7Kemppainen J, Tsuchida H, Insulin signalling and resistance in patients with chronic heart failure. J Physiol 2003, Jul 1:550(pt1):305- 15.
  • 8JOHN P. KIRWAN. Regular exercise enhances insulin activation of IRS - 1 - associated PI3 - kinase in human skeletal muscle . J. Appl. Physiol 2000, 88:797 - 803.
  • 9Hayashi T, Wojtaszewski JF, Goodyear LJ. Exercise regulation of glucose transport in skeletal muscle. Am J Physiol,1997,273(6 Pt 1) :E1039-51.
  • 10Booth FW Chakrayarthy MV, Spangenburg EE. Exercise and gene expression : Physiological regulation of the human genome through physical activity.J Physiol 2002,543(Pt2):399-411.

引证文献5

二级引证文献15

国外医学（老年医学分册）
2001年 第4期

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