Graves病遗传度及其临床意义

The heritability of Graves′ disease and its clinical significance

目的 计算Graves病 (GD)的遗传度 ,讨论其临床意义。方法 调查 5 2 6例GD患者的196 8名一级亲属中GD患者数 ,根据Falconer公式计算遗传度。结果 GD遗传度为 45 % ,低于既往国内报道的结果。结论 GD的发生受遗传和环境因素的影响 。

Objective To investigate the heritability of Graves′ disease (GD) and to discuss its clinical significance. Methods The heritability of GD was calculated using Falconer′s formula and by investigating the GD numbers of 1968 first relatives of 526 established GD patients. Results The heritability of GD was 45%, appearantlymuchlowerthanthoseofprevious reports in China. Conclusion The onset of GD is affected by both inheritant and environmental factors, the latter seems to be predominant over the former.