感觉统合失调儿童血清儿茶酚胺能递质水平及相关行为的研究

Serum levels of catecholamine transmitters and related behaviors in children with sensory integrative dysfunction

目的 探讨感觉统合失调儿童血清儿茶酚胺递质水平与相关行为的关系。方法 采用放射免疫方法定量检测 40例感觉统合失调儿童 (研究组 )及 46名健康儿童 (对照组 )的血清肾上腺素(A)、去甲肾上腺素 (NE)、多巴胺 (DA)水平 ,并比较两组的注意力缺陷次数、智商 (IQ)、心率及学习困难出现率。结果 研究组的血清A为 (0 6 4± 0 19)nmol/L ,NE为 (3 2 0± 0 6 6 )nmol/L ,DA为 (1 45±0 2 0 )nmol/L ,均高于对照组 [分别为 (0 5 2± 0 10 )nmol/L、(2 2 3± 0 6 1)nmol/L、(1 31± 0 18)nmol/L],差异有非常显著性和显著性 (P <0 0 1和 0 0 5 )。研究组的注意力缺陷次数 [(8± 1)次 ]多于对照组[5± 2次 ;P <0 0 1],心率 [(83± 6 )次 ]快于对照组 [(78± 3)次 ];P <0 0 1) ,学习困难出现率 (42 % )高于对照组 (15 % ;P <0 0 1) ;IQ水平两组差异无显著性 (P >0 0 5 )。结论 感觉统合失调儿童血清A、NE及DA呈高水平失衡 ,并有与其相关的交感神经活动性行为表现。

Objective To investigate the correlation between serum levels of catecholamine transmitters and related behaviors in children with sensory integrative dysfunction (SID) Methods The levels of adrenaline(A), noradrenalin(NE) and dopamine(DA) in 40 children with SID and 46 healthy children were determined with radioimmunoassay(RIA) Attention defect, Wechsler Intelligence Scale for Children (WISC) IQ, heart rate and the rate of learning difficulty were also measured Results The levels of A, NE and DA in SID group were (0 64± 0 19),(3 20±0 66) and (1 45±0 20)nmol/L respectively, which were significantly higher in SID group than in control group [(0 52±0 10),(2 23±0 61) and (1 31±0 18)nmol/L], ( P <0 01, P <0 01, P <0 05) The number of attention defect, mean heart rate and the rate of learning disorder were significantly higher than that of normal children ( P <0 05, P <0 01, P <0 01 ), but there was no significant difference in IQ between two groups ( P >0 05) Conclusion The higher serum levels of A , NE and DA are in children with SID, and the abnormal changes are closely related to their sympathetic behaviors